Stroke Can Be Debilitating And Deadly. But 5 Breakthroughs In Modern Medicine May Change Outcomes
Stroke is one of the most serious medical emergencies anyone can experience. Regardless of what type of stroke occurs, the basics of the harm are the same: stroke cuts the flow of blood to the brain. The primary reason that stroke is so potentially devastating its swift attack. In an hour or less brain damage can be severe, leading to permanent disability or death.
Happily, both the medical community and the public at large have learned much about this grim condition over the decades. Today more people are aware of the warning signs for stroke, meaning that those who suffer stroke are receiving treatment more quickly.
New tools in modern medicine may pave the way for dramatically reducing or even eliminating the lingering effects of stroke.
But, once the patient has survived those first critical hours, what then? Many strides have been made, but are there new tools in modern medicine that can even more dramatically reduce or even eliminate the lingering effects of stroke?
The answer is yes! Two exciting discoveries have been made that involve naturally occurring growth factors in the brain and body that may hold the key to even more effective emergency room treatment in the future. But that’s not all. The National Stem Cell Institute (NSI), a leading regenerative medicine facility in the U.S., reports that a medical technique presently in wide use across the United States and the world is already being used as an auxiliary aid in improving the results of rehabilitation.
3 Medical Breakthroughs In The Future Of Stroke Treatment
A stroke happens when a blood vessel either bursts or is blocked significantly enough to prevent effective blood flow. Without proper blood flow brain tissue is starved of oxygen and nutrients, and the tissue begins to die. The brain does have repair mechanisms in place for when this occurs, including something called axonal sprouting.
Axons are the long threadlike parts of a nerve cell that carry electrical impulses. Axonal sprouting is the process in which new axons “sprout” from the intact axons in order to re-establish functions such as muscle control. However, the natural occurrence of axonal sprouting after stroke rarely results in full recovery. And, before very recent studies, the element that triggered axonal sprouting was unknown.
Researchers at the University of California, Los Angeles (UCLA) have discovered that a molecule within the brain is crucial in signaling brain tissue to generate new connections after a stroke. These freshly formed connections circumvent damaged tissue, stimulating the brain into make repairs. The findings could potentially pave the way for a new treatment that promotes cerebral restoration and recovery of function after stroke. This is big news in the fight to prevent serious long-term disability in people who have suffered a stroke. The animal model study, over the span of five years, became the first to discover that the molecule known as Growth Differentiation Factor 10 (GDF10) played such an important role in the adult brain.
Should the chemical signals that stimulate limited recovery be identified and developed, it just may be possible to increase brain tissue repair.
Our brains have only a limited ability to recover after stroke. While it is true that the majority of stroke patients now improve afterward, very few make a 100% recovery. But should the chemical signals that stimulate limited recovery be identified and developed as a treatment, it just may be possible to increase brain tissue repair.
The study demonstrated that GDF10 is, indeed, released after a stroke in humans as well as several species of animals. And, in an earlier study, researchers were able to determine which molecules were more prevalent within the brain once the recovery phase that followed stroke had begun.
Armed with this information, the researchers in the UCLA study followed evidence that one of the listed molecules might be a signal instructing the brain to repair itself. So they began testing the molecules that increased the most within the brain after a stroke occurred. The researchers discovered that GDF10 advanced the ability of brain cells to form new connections.
They were also able to identify the signaling systems that were controlling the process. In doing so, they established that GDF10 stimulates the creation of new neural connections after stroke, enabling recovery of a patient’s capacity for controlling body movement.
Identifying all the molecules controlled by GDF10.
The researchers were able to identify every molecule type that is switched on off by GDF10 in brain cells as a reaction to stroke. They studied how the RNA of these brain cells compares to the RNA of comparable brain cells during typical brain development and standard learning, as well as the RNA in brain cells of patients with other illnesses.
They discovered that GDF10 controls a distinct set of molecules that advance recovery after stroke. This finding implies that the regeneration of brain tissue following a stroke is a uniquely deliberate process, not simply the reactivation of the molecules that are switched on during standard brain development.
The team also injected GDF10 into laboratory animals that had suffered strokes, then were able to map the connections within the brain that are related to bodily movements. They compared these connections to several lab animal groups: those that had experienced stroke, but were not administered GDF10; those who had healthy brains, and those that had suffered stroke but exhibited a reduced level of GDF10.
When GDF10 was delivered, connections were noticeably enhanced.
The results indicate that Growth Differentiation Factor 10 is typically accountable for the obvious but limited formation of new neural connections following a stroke. When more GDF10 was delivered, these connections were noticeably enhanced. Not only that, but the new connection formations were seen primarily in a specific type of brain circuit involved in limb control.
This all points to the exciting potential for a regenerative medicine-type treatment that will activate GDF10’s signaling systems. The development of such a treatment may very well significantly enhance post-stroke recovery.
- Neurotrophin 3 (NT3)
Besides GDF10 being largely related to the restoration of motor function after stroke, growth factor growth factor Neurotrophin 3 (NT3) has also been involved with the improvement of brain-to-intramuscular connectivity. The report published in the neurology journal Brain cites how researchers triggered the sprouting of fresh nerve cells by injecting NT3 intramuscularly into laboratory animals.
These results seem to point beyond neuroprotection, and open up the possibility of an exciting field of medical developments for stroke.
Like research into GDF10, the study of Neurotrophin 3 is new and only recently beginning to emerge. So far, under laboratory conditions, NT3 must be administered within twenty-four hours after the onset of a stroke. Perhaps future development will improve this window of possible treatment. But, regardless if NT3 therapy comes into practical use as a 24-hour emergency treatment or one that can be administered after the first critical hours, Neurotrophin 3 continues to show great promise in the future of regenerative medicine.
- Brain Repair Using Glial Cells
Another exciting potential glimpse into future stroke treatment is the possibility of creating functioning nerve cells within the brain with glial cells. Glial cells envelop neurons, providing support and insulation. Glial cells are the most plentiful types of cell in the central nervous system.
If this research bears the right fruit, using glial cells to repair areas of the brain that have suffered stroke damage may be a real breakthrough. It could mean that glial cells might simply replace the cells damaged by stroke with fresh, healthy nerve cells. Presently, the studies are still limited to lab animals. But the evidence to date points to exciting future prospects.
- Stem Cell Therapy
For many in the public, stem cell therapy still dredges up the controversy that was prominent several decades ago. Today, however, the practical application of this crucial element in regenerative medicine is most commonly done with adult stem cells directly harvested from the patient. And as an auxiliary therapy used in conjunction with modern post-stroke treatments, stem cells show enormous potential for upping the game in recovery for stroke patients.
The two primary sources for stem cell therapy are bone marrow and adipose tissue. Both sources are prized for their stores of mesenchymal stem cells (MSCs). MSCs are multi-potent stem cells. They are basis of all healing and regeneration that happen in the body after we are born. Whether muscle, bone, blood, cartilage, neuron, nerve, skin, organ, or hair, all parts of our bodies depend on stem cells to begin the processes of repairing damage, the re-growth of tissue, the reduction of inflammation, and the regeneration of organs.
When damage is detected, stem cells are “assigned” their duties.
Stem cells circulate within the body throughout life. When damage is detected, whether due to illness or injury, the stem cells are “assigned” their duties. For example, a stem cell is signaled to become a skin cell at the site of a cut. Stem cell therapies use this capability and turn it into powerful and effective treatments of many kinds.
One of the most recent clinical trials examining the use of stem cells for stroke therapy was done at Stanford University. The trial’s main focus was to examine the safety of using stem cells for stroke treatment. But improvement for patients based on several standard measures was so impressive, the auxiliary findings were deemed not just statistically significant, but clinically meaningful.
The trial centered on eighteen patients whose average age was 61. The majority of the test subjects had suffered their strokes at least a full year prior to the trial. That is a period of time well past when continued recovery might be traditionally hoped for. It was shown that test subjects had significant recovery based on a number of measures. Recovery occurred within a month’s time, and improvement continued for several months thereafter.
The improvements were still evident at six and twelve months after the patients received the therapy. Motor function recovered dramatically, something considered unprecedented prior to the trial. Traditionally, physical recovery six months after stroke is not expected.
The preferred stem cell type for most therapies today is adipose-derived stem cells.
The majority of today’s stem cell therapies in the United States are done with adipose-derived stem cells. Adipose tissue is the fatty layer that lies just beneath the skin. It is prized for stem cell therapy because it holds the most abundant source of MSCs, even beyond the stores found in bone marrow. Adipose-stored stem cells are also exceptional in their potency. This source of MSCs is also much more easily accessed than those in bone marrow, making the harvesting of the stem cells considerably less invasive and easier on the patient. The discovery of MSCs in adipose tissue has ushered in an explosion of safe, effective therapies that can now be done on an outpatient basis.
FDA guidelines-compliant stem cell therapy is already in use for a wide variety of illnesses, injuries, and chronic conditions, including:
- Autoimmune Diseases
- Back Pain/Injury
- Chronic Obstructive Pulmonary Disease (COPD)
- Erectile Dysfunction (ED)
- Joint Pain/Injury
- Kidney Conditions
- Multiple Sclerosis
- Parkinson’s Disease
- Reflex Sympathetic Dystrophy (RSD)
- Spinal Cord Injury
The news coming out of medical research fields implies that stem cell therapy for stroke may very well be on the horizon. Because of research and trials like the ones noted in this article, we understand that the re-growth of brain cells and the improvement of neurological functions are possible. It is surely only a matter of time before fully developed treatments based on regenerative medicine methods will be the norm in stroke therapy and recovery.
Does this mean that one day the debilitating aftereffects of stroke will be relegated to medical history? It’s beginning to seem more and more likely.
Learn More At The National Stem Cell Institute
The National Stem Cell Institute (NSI) is a leading regenerative medicine facility located in the United States. It is home to physicians, clinicians, and medical professionals that have undergone post-graduate training in regenerative medicine procedures and/or auxiliary practices such as nutritional counseling and functional rehabilitation that aid healing and promote health during and following PRP and stem cell therapies.
NSI’s mission is to advance patient quality of life through the most advanced developments in regenerative medicine technology, in order to reverse illness, whether physical or neurological, and heal tissues while avoiding invasive surgery and potentially risky medications.
Regenerative medicine facilities are popularly known as stem cell clinics. Regardless of what they are called, the National Stem Cell Institute strongly urges patients interested in regenerative medicine to thoroughly research clinics and medical facilities in order to ensure they are under the care of licensed medical professionals that have been trained in regenerative medical methods.
Below, NSI offers information and tips on what to look for in a licensed stem cell clinic. Those who have questions are encouraged to contact NSI.
What to Look for in a Stem Cell Medical Clinic
When searching for a qualified stem cell therapy center it’s important to remember that not all of them are created equal. Stem cells, when used properly, are your body’s most powerful means for healing that can repair everything from ligaments, tendons, and cartilage to organs including your liver, pancreas and lungs and even neurological tissue like your brain, nerves and spinal cord.
Unfortunately, the majority of so-called “regenerative medicine clinics” in the world aren’t trained in the latest, most technologically advanced procedures and will, therefore, provide poor results if any.
The good news is the National Stem Cell Institute (NSI) has established the most advanced stem cell and platelet rich plasma procedures on the planet which has drawn patients from all over the world as well as professional athletes and celebrities because they are recognized as the best in the world at stem cell therapy.
What makes NSI Stem Cell the top stem cell clinic in the world is demonstrated in 5 key areas:
1. Highly trained and experienced, board-certified doctors and team members who have performed stem cell procedures on thousands of patients with incredible results.
2. Cutting edge procedures utilizing all that regenerative medicine has to offer for many chronic degenerative conditions.
3. Leading scientific researchers who follow the advanced guidelines to maximize the healing potential of your stem cells and to maintain compliance and ethics
4. Use of only the most potent and viable resource of living, viable stem cells and harvested on the same day. No vial that you can purchase will contain living stem cells. If there is no harvest then there are no stem cells.
5. Post-operative guidance for supporting stem-cell growth including rehabilitation, diet and supplement protocols. NSI is a full-service healthcare center focused on patient outcomes. Stem cell therapy is only one tool used to help improve patients’ lives.
Patients have raved about their experience at NSI Stem Cell Clinics testifying that it was their unique cutting-edge procedures that helped them experience a breakthrough when nothing else worked.
If you want to learn more about NSI Stem Cell Clinics, you can set up a complimentary consultation today to see if you are a candidate. You can contact the National Stem Cell Institute at (877) 278-3623.