What Do We Know Now About Multiple Sclerosis Causes?
Multiple sclerosis (MS) is an autoimmune disorder that can affect each person differently. Though MS can go into remission and is not always progressive, a cure for MS is still elusive. Multiple sclerosis causes a variety of physical and neurological symptoms.
At the source of these symptoms is the deterioration of the myelin sheath, the layer of insulation that allows electrical impulses to transmit quickly and efficiently along the nerve cells of the body and brain.
Through this deterioration, multiple sclerosis causes can vary in type and severity.
But what causes the myelin sheath to deteriorate in the first place? Are there many multiple sclerosis causes or just one? The National Stem Cell Institute (NSI), a leading regenerative clinic in the United States, hears questions like these regularly from patients undergoing stem cell therapy for MS. Understanding the processes of the disease and possible causes of MS is crucial in addressing symptoms and keeping flare-ups to a minimum.
Multiple Sclerosis Basics
An autoimmune disease is one in which the immune system mistakes parts of the body as foreign invaders. In the case of MS, the immune system targets the myelin sheath that insulates nerve fibers.
When multiple sclerosis causes sufficient damage to this sheath, the affected nerve can’t function or communicate properly with other nerves.
Because any nerve is a target, the combination of symptoms of MS can vary widely from one affected person to another. There are patients who exhibit such mild symptoms that they may not need therapeutic intervention. In others, multiple sclerosis causes symptoms so severe that normal activities and day-to-day tasks become impossible to perform.
Multiple sclerosis is not considered terminal. But it is a life-long condition that may or may not progress.
Multiple sclerosis causes symptoms that include:
- Difficulty in walking
- Fatigue that ranges from moderate to severe
- Muscular weakness or spasms
- Vision problems
- Neuropathy (numbing or tingling sensations)
- Sexual dysfunction
- Difficulty with bladder or bowel control
- Difficulty with mental focus or memory
Generally speaking, symptoms begin showing up between the ages of 20 and 40. Multiple sclerosis causes cycles of attacks known as relapses. These may not have a regular cycle, and they are generally followed by periods of recovery in which symptoms improve or abate altogether. For some patients, relapses never worsen in intensity or frequency. For others, they worsen as years go by.
Multiple Sclerosis Causes
To date, medical experts don’t have a definitive answer regarding ms causes. However, there continues to be a good deal of progress in learning what may make developing the disease more likely. Among the possible multiple sclerosis causes being studied are genetics, viral infections, and –most recently- a connection to the usually benign bacteria that live in the gut.
Why Science is Studying the Microbiome for Multiple Sclerosis Causes
Our bodies have evolved to host trillions of bacteria within the intestines. These bacteria are known collectively as the gut microbiome. While many are benign or even essential to our health, others have been shown to have links to illnesses that range from eye disease to rheumatoid arthritis.
Two recent studies have now discovered a possible connection between multiple sclerosis causes and gut microbes. The studies indicate that certain intestinal bacteria may cause the immune system to turn attack nerve cells.
If these findings become conclusive, they may lead to discoveries that may develop into actual cures. Already stem cell therapy is showing itself to an effective way to repair the nerve and cellular damage that MS causes.
Could it be that in the future, stem cell therapy will be developed into a bona fide cure?
The Genetic Connection
The majority of researchers believe genetic predisposition plays an important role in whether or not someone develops MS. When someone who has this predisposition encounters a particular environmental trigger, it is thought this convergence causes the immune system to malfunction
Studies previously conducted have identified particular bacteria as possible multiple sclerosis causes. Part of the evidence that supports this is the presence of increased amounts of bacteria in the intestinal tract of people diagnosed with MS. Francisco Quintana, a neuroimmunologist at Brigham and Women’s Hospital in Boston has been quoted as saying, “These are going to be landmark studies.”
How the Studies were Conducted
Sergio Baranzini, a human geneticist at the University of California, San Francisco, led the study that evaluated the microbiomes of 71 people diagnosed with multiple sclerosis. His team also analyzed a control group of 71 healthy people with no disease of any kind. It was discovered that two particular bacterial groups known as Acinetobacter and Akkermansia were four times more abundant in the MS group than the control group of healthy individuals. Just an interesting was the finding that another bacterial group known as Parabacteroides was four times as abundant in healthy participants.
The study on these bacteria as possible multiple sclerosis causes didn’t stop there. The research team introduced what are known as naïve immune cells taken from the healthy control group and exposed these cells to the gut bacteria present in the MS group. Depending on the kind of bacterial invader they encounter, naïve immune cells become different types of cells. When the naïve immune cells came in contact with the Acinetobacter and Akkermansia bacteria, the cells morphed into a specific type of T helper cell.
This type of T helper cell induces a healthy inflammatory response.
This healthy inflammatory response helped the immune system destroy foreign body invaders and cells that had become infected. Interestingly enough, the researchers also reported that the Acinetobacter group of bacteria then ramped down the production of the regulator T cells, helping to prevent further overreaction of the immune response. All impressive findings in the search for possible multiple sclerosis cause based on bacteria.
The study was further bolstered when the researchers transferred the gut bacteria from the MS control group to laboratory mice that were predisposed to developing a disease similar to multiple sclerosis. Within 20 days, the lab mice that received the bacteria exhibited severe brain inflammation. When the gut bacteria from healthy donors were transferred to mice, the brain inflammation that occurred was far less.
A related study was performed at the Max Planck Institute of Neurobiology in Martinsried, Germany.
In this study, immunologists Gurumoorthy Krishnamoorthy and Hartmut Wekerle led a team that studied the gut microbiomes of 34 sets of identical twins. In each set of twins, only one sibling had developed multiple sclerosis. The bacteria group Akkermansia –one of the two types of bacterial groups used in the University of California study proved to be slightly but significantly more prevalent in twins diagnosed with MS, compared to their healthy siblings. This further bolstered the evidence of certain bacteria as possible multiple sclerosis causes.
As with the University of California study, the Krishnamoorthy/ Wekerle team of researchers introduced the gut microbes from the twins into mice predisposed to develop a disease akin to multiple sclerosis. And 12 weeks afterward, it was found that 3 times as many mice that received bacteria from the MS siblings developed brain inflammation as those that received bacteria from the healthy twins. Additionally, it seemed that intestinal microbes from the twins with multiple sclerosis also blocked the production of molecules that are known to reduce inflammation.
More Research into Multiple Sclerosis Causes Continues
Of course, much more research is underway to discover core multiple sclerosis causes and triggers. Nevertheless, these examples of the progress that medical science is making show why present therapies like stem cell procedures are helping to significantly reduce symptoms and the severity of flare-ups in MS patients. They are also demonstrating why regenerative medicine techniques, such as the introduction of native immune cells, may well pave the way for a true MS cure.
About the National Stem Cell Institute
The National Stem Cell Institute (NSI) is a leading regenerative medicine cell clinic based in the United States. NSI specializes in stem cell therapy and platelet-rich plasma therapy. From relieving the symptoms that multiple sclerosis causes to treating COPD and injuries of the spine and joints, NSI has helped patients recover from disease, heal from injury, and improve quality of life.
NSI is a fully licensed regenerative medicine facility in the United States that strictly adheres to FDA guidelines. NSI encourages the public to call with any questions regarding stem cell therapy and how it may pertain to any health concerns. Below, NSI offers tips on selecting the right stem cell clinic for you.
What to Look for in a Stem Cell Medical Clinic
When searching for a qualified stem cell therapy center it’s important to remember that not all of them are created equal. Stem cells, when used properly, are your body’s most powerful means for healing that can repair everything from ligaments, tendons, and cartilage to organs including your liver, pancreas and lungs and even neurological tissue like your brain, nerves, and spinal cord.
Unfortunately, the majority of so-called “regenerative medicine clinics” in the world aren’t trained in the latest, most technologically advanced procedures and will, therefore, provide poor results if any.
The good news is the National Stem Cell Institute (NSI) has established the most advanced stem cell and platelet rich plasma procedures on the planet which has drawn patients from all over the world as well as professional athletes and celebrities because they are recognized as the best in the world at stem cell therapy.
What makes NSI Stem Cell the top stem cell clinic in the world is demonstrated in 5 key areas:
1. Highly trained and experienced, board-certified doctors and team members who have performed stem cell procedures on thousands of patients with incredible results.
2. Cutting edge procedures utilizing all that regenerative medicine has to offer for many chronic degenerative conditions.
3. Leading scientific researchers who follow the advanced guidelines to maximize the healing potential of your stem cells and to maintain compliance and ethics
4. Use of only the most potent and viable resource of living, viable stem cells and harvested on the same day. No vial that you can purchase will contain living stem cells. If there is no harvest then there are no stem cells.
5. Post-operative guidance for supporting stem-cell growth including rehabilitation, diet and supplement protocols. NSI is a full-service healthcare center focused on patient outcomes. Stem cell therapy is only one tool used to help improve patients’ lives.
Patients have raved about their experience at NSI Stem Cell Clinics testifying that it was their unique cutting-edge procedures that helped them experience a breakthrough when nothing else worked.
If you want to learn more about NSI Stem Cell Clinics, you can set up a complimentary consultation today to see if you are a candidate. You can contact the National Stem Cell Institute at (877) 278-3623.
* Disclaimer: Individual patient results may vary. As each patient’s problem is different, each treatment must be tailored around your specific needs.